Anti-APAF1 Aptamer SELEX Service(Cat#: CTApt-2412)

Name: Anti-APAF1 Aptamer SELEX Service
SKU: CTApt-2412
Rating: 5 (1 reviews)

This is an aptamer development services to screening aptamers binds to the APAF1 with an affinity of 1nM~1μM.

Certificate of Analysis Lookup

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Lot Number

Specifications

Target Category	Protein
Target	APAF1
Alternative Names	Apoptotic Peptidase Activating Factor 1; APAF-1; Apoptotic Protease-Activating Factor 1; CED4; Apoptotic Peptidase Activating Factor; Apoptotic Protease Activating Factor; KIAA0413; APAF1
Gene ID	317
UniProt ID	O14727
Target Overview	This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
Chemical Modification	N/A
Type	DNA
Length	20-80 nt
Affinity (Kd)	1nM~1μM
Binding Conditions/Buffer	PBS; buffer system with Serum; other