Anti-APH1A Aptamer SELEX Service(Cat#: CTApt-2111)
This is an aptamer development services to screening aptamers binds to the APH1A with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
APH1A |
| Alternative Names |
Aph-1 Homolog A, Gamma-Secretase Subunit; Presenilin-Stabilization Factor; Gamma-Secretase Subunit APH-1A; APH1A Gamma Secretase Subunit; Aph-1alpha; APH-1A; CGI-78; Anterior Pharynx Defective 1 Homolog A (C. Elegans) ; Anterior Pharynx Defective 1 Homolog A; 6530402N02Rik; APH-1a; APH-1; APH1A; PSF |
| Gene ID |
51107 |
| UniProt ID |
Q96BI3 |
| Target Overview |
This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
