Anti-APOE Aptamer(Cat#: CTApt-2128)

This product is an aptamer which binds to APOE with an affinity of 1-50 nM.

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Summary

Specifications
Target Category Protein
Target APOE
Alternative Names ApoE; Apolipoprotein E; Alzheimer Disease 2 (APOE*E4-Associated, Late Onset); Apolipoprotein E3; LDLCQ5; APO-E; ApoE4; Apo-E; APOE; AD2; LPG
Gene ID 348
UniProt ID P02649
Target Overview The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants.
Type DNA
Length 50-100 nt
Affinity (Kd) 1-50 nM
Binding Conditions/Buffer PBS with 1 mM MgCl2 and 0.025% Tween 20, pH 7.4
GC Content 50.00%
Molecular Weight 31022.2 g/mole
nmoles/OD260 0.937
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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