Anti-APOH Aptamer SELEX Service(Cat#: CTApt-2130)
This is an aptamer development services to screening aptamers binds to the APOH with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
APOH |
| Alternative Names |
Apolipoprotein H; Apolipoprotein H (Beta-2-Glycoprotein I) ; Activated Protein C-Binding Protein; Anticardiolipin Cofactor; Beta-2-Glycoprotein I; Beta-2-Glycoprotein 1; APC Inhibitor; Beta(2)GPI; B2GPI; Apo-H; B2G1; BG; Epididymis Secretory Sperm Binding Protein; B2GP1; APOH |
| Gene ID |
350 |
| UniProt ID |
P02749 |
| Target Overview |
Apolipoprotein H, also known as beta-2-glycoprotein I, is a component of circulating plasma lipoproteins. It has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, hemostasis, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome (APS). The anti-beta (2) glycoprotein I antibodies from APS patients, mediate inhibition of activated protein C which has anticoagulant properties. Because beta-2-GPI is the main autoantigen in patients with APS, the disruption of this pathway by autoantibodies may be an important mechanism for thrombosis in patients with APS. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
