Anti-ARNT Aptamer SELEX Service(Cat#: CTApt-2189)

This is an aptamer development services to screening aptamers binds to the ARNT with an affinity of 1nM~1μM.

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Summary

Specifications
Target Category Protein
Target ARNT
Alternative Names Aryl Hydrocarbon Receptor Nuclear Translocator; BHLHe2; Class E Basic Helix-Loop-Helix Protein 2; Dioxin Receptor, Nuclear Translocator; HIF-1-Beta; HIF-1beta; HIF1-Beta; Hypoxia-Inducible Factor 1, Beta Subunit; Hypoxia-Inducible Factor 1-Beta; ARNT Protein; HIF1BETA; BHLHE2; HIF1B; TANGO; ARNT
Gene ID 405
UniProt ID P27540
Target Overview This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants.
Chemical Modification N/A
Type DNA
Length 20-80 nt
Affinity (Kd) 1nM~1μM
Binding Conditions/Buffer PBS; buffer system with Serum; other
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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