Anti-ARTN Aptamer SELEX Service(Cat#: CTApt-2206)

This is an aptamer development services to screening aptamers binds to the ARTN with an affinity of 1nM~1μM.

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Certificate of Analysis Lookup

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Lot Number

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Summary

Specifications
Target Category Protein
Target ARTN
Alternative Names Artemin; Neublastin; EVN; ENOVIN; NBN; Neurotrophic Factor; Enovin; ARTN; ART
Gene ID 9048
UniProt ID Q5T4W7
Target Overview This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma.
Chemical Modification N/A
Type DNA
Length 20-80 nt
Affinity (Kd) 1nM~1μM
Binding Conditions/Buffer PBS; buffer system with Serum; other
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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