Anti-ASXL1 Aptamer SELEX Service(Cat#: CTApt-2450)

This is an aptamer development services to screening aptamers binds to the ASXL1 with an affinity of 1nM~1μM.

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Summary

Specifications
Target Category Protein
Target ASXL1
Alternative Names ASXL Transcriptional Regulator 1; Additional Sex Combs Like 1, Transcriptional Regulator; Polycomb Group Protein ASXL1; KIAA0978; Additional Sex Combs Like Transcriptional Regulator 1; Additional Sex Combs Like 1 (Drosophila) ; Putative Polycomb Group Protein ASXL1; Additional Sex Combs-Like Protein 1; ASXL1; BOPS; MDS
Gene ID 171023
UniProt ID Q8IXJ9
Target Overview This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.
Chemical Modification N/A
Type DNA
Length 20-80 nt
Affinity (Kd) 1nM~1μM
Binding Conditions/Buffer PBS; buffer system with Serum; other
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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