Anti-ATP6V0A4 Aptamer SELEX Service(Cat#: CTApt-2548)

This is an aptamer development services to screening aptamers binds to the ATP6V0A4 with an affinity of 1nM~1μM.

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Summary

Specifications
Target Category Protein
Target ATP6V0A4
Alternative Names ATPase H+ Transporting V0 Subunit A4; ATPase, H+ Transporting, Lysosomal V0 Subunit A4; ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump) Non-Catalytic Accessory Protein 1B; Vacuolar Proton Translocating ATPase 116 KDa Subunit A Kidney Isoform; V-Type Proton ATPase 116 KDa Subunit A Isoform 4; ATP6N1B; ATP6N2; RDRTA2; RTADR; VPP2; A4; ATPase, H+ Transporting, Lysosomal (Vacuolar Proton Pump) Non-Catalytic Accessory Protein 2 (38kD) ; H(+)-Transporting Two-Sector ATPase, Noncatalytic Accessory Protein 1B; Vacuolar Proton Translocating ATPase 116 KDa Subunit A Isoform 4; ATPase, H+ Transporting, Lysosomal V0 Subunit A Isoform 4; Vacuolar Proton Pump 116 KDa Accessory Subunit; V-Type Proton ATPase 116 KDa Subunit A; Vacuolar Proton Pump, Subunit 2; V-ATPase 116 KDa Isoform A4; V-ATPase 116 KDa; ATP6V0A4; RTA1; STV1; VPH1; Vph1; Stv1
Gene ID 50617
UniProt ID Q9HBG4
Target Overview This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing.
Chemical Modification N/A
Type DNA
Length 20-80 nt
Affinity (Kd) 1nM~1μM
Binding Conditions/Buffer PBS; buffer system with Serum; other
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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