Anti-ATRX Aptamer SELEX Service(Cat#: CTApt-2409)
This is an aptamer development services to screening aptamers binds to the ATRX with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
ATRX |
| Alternative Names |
ATRX Chromatin Remodeler; XH2; XNP; Transcriptional Regulator ATRX; ATP-Dependent Helicase ATRX; X-Linked Nuclear Protein; X-Linked Helicase II; RAD54L; Alpha Thalassemia/Mental Retardation Syndrome X-Linked (RAD54 (S. Cerevisiae) Homolog) ; Alpha Thalassemia/Mental Retardation Syndrome X-Linked (RAD54 Homolog, S. Cerevisiae) ; Alpha Thalassemia/Mental Retardation Syndrome X-Linked; Mental Retardation, X-Linked 52; RAD54 Homolog (S. Cerevisiae) ; Juberg-Marsidi Syndrome; EC 3.6.1'); ; EC 3.6.4.12; EC 3.6.1; ZNF-HX; Znf-HX; MRX52; RAD54; ATRX; JMS |
| Gene ID |
546 |
| UniProt ID |
P46100 |
| Target Overview |
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
