Anti-AUH Aptamer SELEX Service(Cat#: CTApt-2302)
This is an aptamer development services to screening aptamers binds to the AUH with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
AUH |
| Alternative Names |
AU RNA Binding Methylglutaconyl-CoA Hydratase; AU RNA-Binding Protein/Enoyl-Coenzyme A Hydratase; Methylglutaconyl-CoA Hydratase, Mitochondrial; AU-Specific RNA-Binding Enoyl-CoA Hydratase; AU RNA Binding Protein/Enoyl-CoA Hydratase; AU-Binding Protein/Enoyl-CoA Hydratase; Itaconyl-CoA Hydratase; AU RNA Binding Protein/Enoyl-Coenzyme A Hydratase; 3-Methylglutaconyl-CoA Hydratase; EC 4.2.1.18; EC 4.2.1.56; AUH |
| Gene ID |
549 |
| UniProt ID |
Q13825 |
| Target Overview |
This gene encodes bifunctional mitochondrial protein that has both RNA-binding and hydratase activities. The encoded protein is a methylglutaconyl-CoA hydratase that catalyzes the hydration of 3-methylglutaconyl-CoA to 3-hydroxy-3-methyl-glutaryl-CoA, a critical step in the leucine degradation pathway. This protein also binds AU-rich elements (AREs) found in the 3' UTRs of rapidly decaying mRNAs including c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. This protein is localizes to the mitochondrial matrix and the inner mitochondrial membrane and may be involved in mitochondrial protein synthesis. Mutations in this gene are the cause of 3-methylglutaconic aciduria, type I. Alternative splicing results in multiple transcript variants. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
