Anti-BCL2L1 aptamer(Cat#: CTApt-1718)
This product is an aptamer which binds to the BCL2L1 with an affinity of 1nM~1μM.
Specific Inquiry 
Summary
Related Products & Services
Specifications
| Target Category |
Protein |
| Target |
BCL2L1 |
| Alternative Names |
BCL2 Like 1; BCL2L; BCLX; Protein Phosphatase 1, Regulatory Subunit 52; Apoptosis Regulator Bcl-X; Bcl-2-Like Protein 1; PPP1R52; Bcl-X; BCL-XL/S; Bcl2-L-1; BCL2L; Bcl-XL; Bcl-XS |
| Gene ID |
598 |
| UniProt ID |
Q07817 |
| Target Overview |
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. |
| Chemical Modification |
DNA/RNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
