This is an aptamer development services to screening aptamers binds to the BCL2L12 with an affinity of 1nM~1μM.
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| Target Category | Protein |
| Target | BCL2L12 |
| Alternative Names | BCL2 Like 12; BCL2-Like 12 (Proline Rich) ; Bcl-2-Like Protein 12; Bcl-2 Related Proline-Rich Protein; Bcl-2-Related Proline-Rich Protein; Bcl2-L-12; BCL2L12; BPR |
| Gene ID | 83596 |
| UniProt ID | Q9HB09 |
| Target Overview | This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. |
| Chemical Modification | N/A |
| Type | DNA |
| Length | 20-80 nt |
| Affinity (Kd) | 1nM~1μM |
| Binding Conditions/Buffer | PBS; buffer system with Serum; other |