Anti-BIN1 aptamer SELEX Service(Cat#: CTApt-1745)
This is an aptamer development services to screening aptamers binds to the BIN1 with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
BIN1 |
| Alternative Names |
Bridging Integrator 1; Amphiphysin II; Myc Box-Dependent-Interacting Protein 1; Box-Dependent Myc-Interacting Protein 1; Amphiphysin-Like Protein; AMPH2; AMPHL; SH3P; Box Dependant MYC Interacting Protein 1; CNM2; BIN1 |
| Gene ID |
274 |
| UniProt ID |
O00499 |
| Target Overview |
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
