Anti-BRAF aptamer SELEX Service(Cat#: CTApt-1789)
This is an aptamer development services to screening aptamers binds to the BRAF with an affinity of 1nM~1μM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
BRAF |
| Alternative Names |
B-Raf Proto-Oncogene, Serine/Threonine Kinase; BRAF1; V-Raf Murine Sarcoma Viral Oncogene Homolog B1; V-Raf Murine Sarcoma Viral Oncogene Homolog B; Serine/Threonine-Protein Kinase B-Raf; Proto-Oncogene B-Raf; RAFB1; B-Raf Proto-Oncogene Serine/Threonine-Protein Kinase (P94) ; Murine Sarcoma Viral (V-Raf) Oncogene Homolog B1; B-Raf Serine/Threonine-Protein; 94 KDa B-Raf Protein; EC 2.7.11.1; B-RAF1; B-Raf; BRAF; NS7; P94 |
| Gene ID |
673 |
| UniProt ID |
P15056 |
| Target Overview |
This gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome. |
| Chemical Modification |
N/A |
| Type |
DNA |
| Length |
20-80 nt |
| Affinity (Kd) |
1nM~1μM |
| Binding Conditions/Buffer |
PBS; buffer system with Serum; other |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
