Anti-BRCC3 aptamer SELEX Service(Cat#: CTApt-1791)

This is an aptamer development services to screening aptamers binds to the BRCC3 with an affinity of 1nM~1μM.

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Summary

Specifications
Target Category Protein
Target BRCC3
Alternative Names BRCA1/BRCA2-Containing Complex Subunit 3; BRCC36; C6.1A; BRCA1/BRCA2-Containing Complex Subunit 36; Lys-63-Specific Deubiquitinase BRCC36; BRCA1-A Complex Subunit BRCC36; BRISC Complex Subunit BRCC36; CXorf53; BRCA1/BRCA2-Containing Complex, Subunit 3; Chromosome X Open Reading Frame 5; Lys-63-Specific Deubiquitinase; EC 3.1.2.15; BRCC3
Gene ID 79184
UniProt ID P46736
Target Overview This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.
Chemical Modification N/A
Type DNA
Length 20-80 nt
Affinity (Kd) 1nM~1μM
Binding Conditions/Buffer PBS; buffer system with Serum; other
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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