Anti-Carbonic Anhydrase IX Aptamer(Cat#: CTApt-M-1222)

This product is an aptamer which binds to the CA9 with a high affinity.

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5’ Modification
 
3’ Modification
 
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Specifications
Target Category Protein
Target CA9
Alternative Names Carbonic Anhydrase 9; CAIX; MN; Carbonic Anhydrase IX; Renal Cell Carcinoma-Associated Antigen G250; RCC-Associated Protein G250; RCC-Associated Antigen G250; Carbonate Dehydratase IX; Carbonic Dehydratase; Membrane Antigen MN; P54/58N; CA-IX; PMW1; EC 4.2.1.1; G250
Gene ID 768
UniProt ID Q16790
Target Overview Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.
Chemical Modification DNA
Length 60-80 nt
Affinity (Kd) N/A
Binding Conditions/Buffer 1x PBS

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For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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