Anti-CD16α aptamer(Cat#: CTApt-2043)

This product is an aptamer which binds to the CD16α with an affinity of <50 nM.

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Summary

Specifications
Target Category Protein
Target CD16α
Alternative Names Fc Fragment Of IgG Receptor IIIa; Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A; Fc Fragment Of IgG, Low Affinity IIIa, Receptor (CD16a) ; IgG Fc Receptor III-2; Fc-Gamma RIII-Alpha; CD16a Antigen; CD16A; FCGR3; IGFR3; CD16; FCG3; Low Affinity Immunoglobulin Gamma Receptor III-A Fc Fragment; Fc Fragment Of IgG, Low Affinity IIIa, Receptor For (CD16) ; Fc Fragment Of IgG, Low Affinity III, Receptor For (CD16) ; Immunoglobulin G Fc Receptor III; Fc-Gamma Receptor III-2 (CD 16) ; Neutrophil-Specific Antigen NA; Fc-Gamma Receptor IIIb (CD16) ; Fc Gamma Receptor III-A; Fc Gamma Receptor IIIa; Fc-Gamma RIIIa; Fc-Gamma RIII; FcgammaRIIIA; FCGRIII; FCRIIIA; FcRIIIa; FCR-10; FCRIII; FCGR3A; FcRIII; FcR-10; IMD20; CD16a
Gene ID 2214
UniProt ID P08637
Target Overview This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Chemical Modification DNA
Length 20-40 nt
Affinity (Kd) <50 nM
Binding Conditions/Buffer 0.05% BSA in DPBS
GC Content 0.59
Molecular Weight 10612.9
nmoles/OD260 2.615
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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