This product is an aptamer which binds to the Chloramphenicol with an affinity of <100 nM.
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| Target Category | Small Organic |
| Target | Chloramphenicol |
| Alternative Names | chloramphenicol; 56-75-7; Chloromycetin; Chlornitromycin; Levomycetin |
| Target Overview | Chloramphenicol is a broad spectrum antibiotic introduced into clinical practice in 1948, but which was subsequently shown to cause serious and fatal aplastic anemia and is now used rarely and reserved for severe, life-threatening infections for which other antibiotics are not available. Chloramphenicol has also been linked to cases of acute, clinically apparent liver injury with jaundice, largely in association with aplastic anemia. |
| Chemical Modification | RNA |
| Length | 40-60 nt |
| Affinity (Kd) | <100 nM |
| Binding Conditions/Buffer | 20 mM MgCl2, 400 mM NaCl, 100 mM bis-Tris (pH 6.4). |
| GC Content | 0.42 |
| Molecular Weight | 16189.95 g/mole |
| Extinction Coefficient | 522900 L/(mole·cm) |
| nmoles/OD260 | 1.91 |