Anti-EIF4E Aptamer(Cat#: CTMM-0123-MM2)

Name: Anti-EIF4E Aptamer
SKU: CTMM-0123-MM2

This product is an aptamer which binds to the eIF4E with an affinity of <20 nM.

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Specifications

Target Category	Protein
Target	eIF4E
Alternative Names	Eukaryotic Translation Initiation Factor 4E, EIF4EL1, EIF4E1, EIF4F, MRNA Cap-Binding Protein, EIF-4F 25 KDa Subunit, EIF-4E, Eukaryotic Translation Initiation Factor 4E-Like, AUTS19, EIF4E, CBP
Gene ID	1977
UniProt ID	P06730
Target Overview	The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants.
Chemical Modification	RNA
Length	80-100 nt
Affinity (Kd)	<20 nM
Binding Conditions/Buffer	20 mM Tris-HCl at pH 7.6, 80 mM potassium acetate, 2.5 mM magnesium acetate, 1 mM dithiothreitol, 5% glycerol
GC Content	0.51
Molecular Weight	30069.3
nmoles/OD260	0.888

Customer Review

High specificity and binding affinity

Excellent

The product was delivered with detailed protocol guidelines, which made it easy to integrate into our existing experiments.

This aptamer has significantly improved the accuracy of our assays

Excellent

The aptamer's ability to selectively bind to EIF4E without affecting other proteins has proven invaluable. The results have been reproducible, and the data quality is excellent. One downside was a bit of a learning curve with the protocol, but the support team was very helpful.

I was impressed by the performance

Excellent

The aptamer's binding characteristics were just as advertised, providing high specificity and minimal background noise. The product met all our expectations.

A reliable tool

Excellent

Its performance in our experiments has been consistent, and the data generated has been robust. We appreciated the comprehensive user manual provided, which helped streamline our experimental setup.

The product quality is high, and the support team is very responsive

Excellent

Its ability to specifically bind to EIF4E without cross-reacting with other proteins has enabled us to explore new avenues of research. The protocol was straightforward, but some optimization was needed initially. Overall, a very effective research tool.

For Research Use Only. Not for Diagnostic or Therapeutic Applications.

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