Anti-ERBB3 Aptamer(Cat#: CTApt-M-1068)
This product is an aptamer which binds to the ERBB3 with an affinity of <50 nM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
ERBB3 |
| Alternative Names |
Erb-B2 Receptor Tyrosine Kinase 3; HER3; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 3; Tyrosine Kinase-Type Cell Surface Receptor HER3; Human Epidermal Growth Factor Receptor 3; Receptor Tyrosine-Protein Kinase ErbB-3; Proto-Oncogene-Like Protein C-ErbB-3; EC 2.7.10.1; LCCS2; Lethal Congenital Contracture Syndrome 2; P180-ErbB3; P45-SErbB3; P85-SErbB3; EC 2.7.10; MDA-BF-1; C-ErbB-3; C-ErbB3; ErbB3-S; ErbB-3; FERLK |
| Gene ID |
2065 |
| UniProt ID |
P21860 |
| Target Overview |
This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. |
| Chemical Modification |
RNA |
| Length |
60-80 nt |
| Affinity (Kd) |
<50 nM |
| Binding Conditions/Buffer |
Binding buffer: 10 mM HEPES (pH 7.4), 100 mM NaCl, and 2.5 mM MgCl2 |
| GC Content |
59.49% |
| Molecular Weight |
25442.28 g/mole |
| Extinction Coefficient |
761100 L/(mole·cm) |
| nmoles/OD260 |
1.31 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
