This is an aptamer development services to screening aptamers binds to the GPA33 with an affinity of 1nM~1μM.
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| Target Category | Protein |
| Target | GPA33 |
| Alternative Names | Glycoprotein A33; Glycoprotein A33 (Transmembrane) ; Cell Surface A33 Antigen; A33; Transmembrane Glycoprotein A33; GPA33 |
| Gene ID | 10223 |
| UniProt ID | Q99795 |
| Target Overview | The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. |
| Chemical Modification | N/A |
| Type | DNA |
| Length | 20-80 nt |
| Affinity (Kd) | 1nM~1μM |
| Binding Conditions/Buffer | PBS; buffer system with Serum; other |