Anti-Human AGT Aptamer(Cat#: CTMM-0124-LH4)
This product is an aptamer which binds to Human AGT domain with an affinity of 1-50 nM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
AGTX2 |
| Alternative Names |
Glyoxylate Aminotransferase 2; AGT2; Beta-Alanine-Pyruvate Aminotransferase; Beta-ALAAT II; Alanine--Glyoxylate Aminotransferase 2, Mitochondrial; (R)-3-Amino-2-Methylpropionate--Pyruvate Transaminase; Alanine-Glyoxylate Aminotransferase 2; EC 2.6.1.44; EC 2.6.1.40; D-AIBAT; DAIBAT; BAIBA; AGT 2 |
| Gene ID |
183 |
| UniProt ID |
P1019 |
| Target Overview |
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure, body fluid and electrolyte homeostasis, and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. |
| Type |
DNA |
| Species Reactivity |
Human; Rat |
| Length |
50-100 nt |
| Affinity (Kd) |
1-50 nM |
| Binding Conditions/Buffer |
PBS, pH=7.4 |
| GC Content |
48.81% |
| Molecular Weight |
25237.5 g/mole |
| nmoles/OD260 |
1.138 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
