Anti-Human AXL Aptamer(Cat#: CTMM-0124-RJ7)

This product is an aptamer which binds to Human AXL with an affinity of 1-50 nM.

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Lot Number

TOP
Summary Related Products & Services

Specifications
Target Category Protein
Target AXL
Alternative Names AXL Receptor Tyrosine Kinase; UFO; JTK11; Tyro7; ARK; Tyrosine-Protein Kinase Receptor UFO; AXL Oncogene; EC 2.7.10.1; AXL Transforming Sequence/Gene; EC 2.7.10; AXL
Gene ID 558
UniProt ID P30530
Target Overview The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus.
Chemical Modification dTTP was substituted with Bz-dU or Nap-Du
Type DNA
Species Reactivity Human
Length 50-100 nt
Affinity (Kd) 1-50 nM
Binding Conditions/Buffer 40 nM HEPES, 120 mM NaCl, 5 mM KCl, 5 mM MgCl2, 0.002% Tween20, pH 7.5
GC Content 58.67%
Molecular Weight 22547.6 g/mole
nmoles/OD260 1.379

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