Anti-Human BCL2A1 Aptamer(Cat#: CTMM-0124-RJ65)

This product is an aptamer which binds to Human BCL2A1 with a high affinity.

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Specifications
Target Category Protein
Target BCL2A1
Alternative Names BCL2 Related Protein A1; BCL2L5; BFL1; GRS; ACC-1; ACC-2; HBPA1; ACC2; ACC1; Hemopoietic-Specific Early Response Protein; Bcl-2-Related Protein A1; Bcl-2-Like Protein 5; Protein BFL-1; Bcl2-L-5; Hematopoietic BCL2-Related Protein A1; Protein GRS; BCL2A1
Gene ID 597
UniProt ID Q16548
Target Overview This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Type Peptide
Species Reactivity Human
Length <50 nt
Binding Conditions/Buffer 200 mM NaCl, 40 mM TrisHCl, 2 mM EDTA, and 1% NP-40, pH 8
Molecular Weight 1486.7 g/mole

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