Anti-Human Factor V/Va Aptamer(Cat#: CTMM-0124-TT36)

This product is an aptamer which binds to the Human Factor V/Va with an affinity of 1-50 nM.

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Summary

Specifications
Target Category Protein
Target F5
Alternative Names Coagulation Factor V; Coagulation Factor V (Proaccelerin, Labile Factor); Activated Protein C Cofactor; Coagulation Factor V Jinjiang A2 Domain; Proaccelerin, Labile Factor; Factor V Leiden; RPRGL1; THPH2; PCCF; FVL
Gene ID 2153
UniProt ID P12259
Target Overview This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance.
Chemical Modification 2'-fluoro pyrimidines
Type RNA
Species Reactivity Human
Length 50-100 nt
Affinity (Kd) 1-50 nM
Binding Conditions/Buffer 20 mM Hepes, BSA, 150 mM NaCl, 2 mM CaCl₂, pH 7.4
GC Content 58.62%
Molecular Weight 17754.30 g/mole
nmoles/OD260 1.86
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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