Anti-Human Factor VIII Aptamer(Cat#: CTMM-0124-TT38)
This product is an aptamer which binds to the Human Factor VIII with an affinity of 200-1000 nM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
F8 |
| Alternative Names |
Coagulation Factor VIII; DXS1253E; FVIII; HEMA; F8C; Coagulation Factor VIII, Procoagulant Component; Antihemophilic Factor; AHF; Coagulation Factor VIII A1 Domain; Coagulation Factor VIII C2 Domain; Coagulation Factor VIIIc; Procoagulant Component; Factor VIII F8B; Factor VIIIF8B; Hemophilia A; THPH13; F8B |
| Gene ID |
2157 |
| UniProt ID |
P00451 |
| Target Overview |
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. |
| Type |
DNA |
| Species Reactivity |
Human |
| Length |
50-100 nt |
| Affinity (Kd) |
200-1000 nM |
| Binding Conditions/Buffer |
Tris 40 mM, NaCl 117 mM, CaCl₂ 5mM and MgCl₂ 5 mM, pH 7.4 |
| GC Content |
53.25% |
| Molecular Weight |
23623.32 g/mole |
| nmoles/OD260 |
1.41 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
