Anti-Human GPC3 Aptamer(Cat#: CTMM-0124-LH27)
This product is an aptamer which binds to Human GPC3 domain with an affinity of 1-50 nM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
GPC3 |
| Alternative Names |
Glypican 3; OCI-5; SGBS1; SGBS; DGSX; SGB; Intestinal Protein OCI-5; Glypican Proteoglycan 3; Glypican-3; GTR2-2; MXR7; SDYS; Heparan Sulphate Proteoglycan; Secreted Glypican-3; OCI5 |
| Gene ID |
2719 |
| UniProt ID |
P51654 |
| Target Overview |
Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. |
| Chemical Modification |
5-(N-benzylcarboxamide)2'-deoxyuridine (Bn-dU) |
| Type |
DNA |
| Species Reactivity |
Human |
| Length |
<50 nt |
| Affinity (Kd) |
1-50 nM |
| Binding Conditions/Buffer |
DPBS with 4.5 g/L glucose, 5 mM MgCl2, 0.1 mg/mL yeast tRNA, and 1 mg/mL BSA |
| GC Content |
40.54% |
| Molecular Weight |
11324.6 g/mole |
| nmoles/OD260 |
2.432 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
