Anti-Human IGHM Aptamer(Cat#: CTMM-0124-RJ27)
This product is an aptamer which binds to Human IGHM with a high affinity.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
IGHM |
| Alternative Names |
Immunoglobulin Heavy Constant Mu; Constant Region Of Heavy Chain Of IgM; Ig Mu Chain C Region BOT; Ig Mu Chain C Region GAL; Immunoglobulin Mu Chain; Ig Mu Chain C Region OU; Ig Mu Chain C Region; AGM1; MU; VH; IGHM |
| Gene ID |
3507 |
| UniProt ID |
P01871 |
| Target Overview |
Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma. |
| Chemical Modification |
Photo-active 5-iodo-deoxyuridine (5-dUI) nucleotides |
| Type |
DNA |
| Species Reactivity |
Human |
| Length |
<50 nt |
| Binding Conditions/Buffer |
0.1 mg/ml Yeast tRNA, 1 mg/ml sheared salmon sperm DNA, 4.5 g/liter glucose and 5 mm MgCl2 in Dulbecco's PBS with calcium chloride and magnesium chloride |
| GC Content |
60.87% |
| Molecular Weight |
13627.8 g/mole |
| nmoles/OD260 |
2.222 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
