Anti-Human IL2RA Aptamer(Cat#: CTMM-0124-LH12)
This product is an aptamer which binds to Human IL2RA domain with an affinity of 1-50 nM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
IL2RA |
| Alternative Names |
CD25; Interleukin 2 Receptor Subunit Alpha; Interleukin-2 Receptor Subunit Alpha; Interleukin 2 Receptor, Alpha; IL-2 Receptor Subunit Alpha; IL-2R Subunit Alpha; TAC Antigen; IDDM10; IL2R; P55; Insulin-Dependent Diabetes Mellitus 10; CD25 Antigen; IL-2-RA; IL2-RA; IMD41; TCGFR |
| Gene ID |
3559 |
| UniProt ID |
P01589 |
| Target Overview |
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. |
| Type |
DNA |
| Species Reactivity |
Human |
| Length |
50-100 nt |
| Affinity (Kd) |
1-50 nM |
| Binding Conditions/Buffer |
50 mM K2HPO4, 150 mM NaCl, 0.05% Tween-20, BSA 1 μg/ml, 0.1 mg/ml yeast tRNA, pH=7.5 |
| GC Content |
58.54% |
| Molecular Weight |
24884.1 g/mole |
| nmoles/OD260 |
1.206 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
