Anti-Human LEP Aptamer(Cat#: CTMM-0124-JS25)

This product is an aptamer that binds to the Human LEP with an affinity of <50 μM.

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Summary

Specifications
Target Category Protein
Target LEP
Alternative Names Leptin; OBS; OB; Leptin (Mouse Obesity Homolog); Leptin (Obesity Homolog; Mouse); Obesity Factor; Obese Protein; Obese; Mouse; Homolog Of; LEPD
Gene ID 3952
UniProt ID P41159
Target Overview This gene encodes a protein that is secreted by white adipocytes into the circulation and plays a major role in the regulation of energy homeostasis. Circulating leptin binds to the leptin receptor in the brain, which activates downstream signaling pathways that inhibit feeding and promote energy expenditure. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis, reproduction, bone formation and wound healing. Mutations in this gene and its regulatory regions cause severe obesity and morbid obesity with hypogonadism in human patients. A mutation in this gene has also been linked to type 2 diabetes mellitus development.
Type DNA
Species Reactivity Human
Length 50-200 nt
Affinity (Kd) <50 nM
Binding Conditions/Buffer 10mM HEPES, 100mM KCl, 1mM EDTA and 0.5% BSA buffer, pH 7.4
GC Content 55.42%
Molecular Weight 24925.14 g/mole
nmoles/OD260 1.37
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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