Anti-Human Lrp6 Aptamer(Cat#: CTMM-0124-JS2)
This product is an aptamer that binds to the Human Low-density lipoprotein receptor-related protein 6 (LRP6) with an affinity of <50 nM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
Low-density lipoprotein receptor-related protein 6 (LRP6) |
| Alternative Names |
LDL Receptor Related Protein 6; ADCAD2; Low-Density Lipoprotein Receptor-Related Protein 6; LRP-6; Low Density Lipoprotein Receptor-Related Protein 6; STHAG7 |
| Gene ID |
4040 |
| UniProt ID |
O75581 |
| Target Overview |
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined. |
| Type |
DNA |
| Species Reactivity |
Human |
| Length |
<50 nt |
| Affinity (Kd) |
<50 nM |
| Binding Conditions/Buffer |
PBST with 0.05% Tween-20, pH 7.4 |
| GC Content |
56.10% |
| Molecular Weight |
24702.03 g/mole |
| nmoles/OD260 |
1.35 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
