Anti-Human/Mouse FGFR3 Aptamer(Cat#: CTMM-0124-TT45)
This product is an aptamer which binds to the Human/Mouse FGFR3 with an affinity of 200-1000 nM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
FGFR3 |
| Alternative Names |
Fibroblast Growth Factor Receptor 3; JTK4; CD333; CEK2; FGFR-3; ACH; Achondroplasia, Thanatophoric Dwarfism; Fibroblast Growth Factor Receptor 3-S; Hydroxyaryl-Protein Kinase; Tyrosine Kinase JTK4; CD333 Antigen; HSFGFR3EX |
| Gene ID |
2261 |
| UniProt ID |
P22607 |
| Target Overview |
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. |
| Chemical Modification |
2'-fluoro pyrimidines |
| Type |
RNA |
| Species Reactivity |
Human; Mouse |
| Length |
<50 nt |
| Affinity (Kd) |
200-1000 nM |
| Binding Conditions/Buffer |
DPBS with MgCl₂ |
| GC Content |
56.76% |
| Molecular Weight |
11257.08 g/mole |
| nmoles/OD260 |
3.13 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
