Anti-Human NGF Aptamer(Cat#: CTMM-0124-LH30)
This product is an aptamer which binds to Human NGF domain with an affinity of 200-1000 pM.
Specific Inquiry 
Summary
Specifications
| Target Category |
Protein |
| Target |
NGF |
| Alternative Names |
Nerve Growth Factor; NGFB; Nerve Growth Factor (Beta Polypeptide); Beta-Nerve Growth Factor; Beta-NGF; Nerve Growth Factor, Beta Subunit; Pro-Nerve Growth Factor Long; HSAN5 |
| Gene ID |
4803 |
| UniProt ID |
P01138 |
| Target Overview |
This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. |
| Chemical Modification |
5-(N-benzylcarboxamide)-2'-deoxyuridine (Bn-dU) replacing dT |
| Type |
DNA |
| Species Reactivity |
Human |
| Length |
<50 nt |
| Affinity (Kd) |
200-1000 pM |
| Binding Conditions/Buffer |
40 mM HEPES, 102 mM NaCl, 5 mM KCl, 5 mM MgCl2, 0.01% TWEEN 20, pH=7.5 |
| GC Content |
50.00% |
| Molecular Weight |
8706.7 g/mole |
| nmoles/OD260 |
3.37 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
