Anti-Human Prekallikrein and Kallikrein Aptamer(Cat#: CTMM-0124-RJ57)
This product is an aptamer which binds to Human Prekallikrein and Kallikrein with an affinity of 200-1000 pM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
prekallikrein and kallikrein |
| Target Overview |
Prekallikrein (PK), also known as Fletcher factor, is an 85,000 Mr serine protease that complexes with high-molecular-weight kininogen. PK is the precursor of plasma kallikrein, which is a serine protease that activates kinins. PK is cleaved to produce kallikrein by activated Factor XII (Hageman factor). Kallikreins are a subgroup of serine proteases, enzymes capable of cleaving peptide bonds in proteins. In humans, plasma kallikrein (encoded by KLKB1 gene) has no known paralogue, while tissue kallikrein-related peptidases (KLKs) encode a family of fifteen closely related serine proteases. |
| Chemical Modification |
2'-fluoro pyrimidines |
| Type |
RNA |
| Species Reactivity |
Human |
| Length |
50-100 nt |
| Affinity (Kd) |
200-1000 pM |
| Binding Conditions/Buffer |
20 mM HEPES, 150 mM NaCl, 2 mM CaCl2, pH 7.4 |
| GC Content |
58.93% |
| Molecular Weight |
16548.5 g/mole |
| nmoles/OD260 |
1.703 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
