Anti-Human PTTG1 Aptamer(Cat#: CTWZ-0124-WZ41)
This product is an aptamer which binds to human PTTG1 with an affinity of 1-50 nM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
PTTG1 |
| Alternative Names |
PTTG1 Regulator Of Sister Chromatid Separation, Securin; HPTTG; PTTG; EAP1; Tumor-Transforming Protein 1; Securin; ECRAR; TUTR1; Endogenous Cardiac Regeneration-Associated Regulator; Pituitary Tumor-Transforming Gene 1 Protein; Pituitary Tumor-Transforming 1; ESP1-Associated Protein 1; Esp1-Associated Protein; SECURIN |
| Gene ID |
9232 |
| UniProt ID |
O95997 |
| Target Overview |
The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. |
| Type |
RNA |
| Species Reactivity |
Human |
| Length |
50-100 nt |
| Affinity (Kd) |
1-50 nM |
| Binding Conditions/Buffer |
10 mM HEPES-KOH and 150 mM NaCl, pH 7.4 |
| GC Content |
57.43% |
| Molecular Weight |
30229.1 g/mole |
| nmoles/OD260 |
0.941 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
