Anti-Human TG Aptamer(Cat#: CTMM-0124-LH42)
This product is an aptamer which binds to Human TG domain with an affinity of 1-50 nM.
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Summary
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Specifications
| Target Category |
Protein |
| Target |
TG |
| Alternative Names |
Thyroglobulin; AITD3; TGN; Tg |
| Gene ID |
7038 |
| UniProt ID |
P01266 |
| Target Overview |
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. |
| Type |
DNA |
| Species Reactivity |
Human |
| Length |
50-100 nt |
| Affinity (Kd) |
1-50 nM |
| Binding Conditions/Buffer |
25 mM Tris-HCl, 1 mM MgCl2, 2.7 mM KCl, and 40 mM NaCl, pH=7.4 |
| GC Content |
54.76% |
| Molecular Weight |
25274.4 g/mole |
| nmoles/OD260 |
1.159 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
