Anti-Human TLR4 Aptamer(Cat#: CTMM-0124-LH44)
This product is an aptamer which binds to Human TLR4 domain with a high affinity.
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Summary
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Specifications
| Target Category |
Protein |
| Target |
TLR4 |
| Alternative Names |
Toll Like Receptor 4; Toll-Like Receptor 4; ARMD10; Htoll; CD284; TLR-4; Toll Like Receptor 4 Protein; Homolog Of Drosophila Toll; CD284 Antigen; HTOLL; TOLL |
| Gene ID |
7099 |
| UniProt ID |
O00206 |
| Target Overview |
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Type |
DNA |
| Species Reactivity |
Human; Rat |
| Length |
50-100 nt |
| Binding Conditions/Buffer |
PBS with 1 mM MgCl2 at 37°C |
| GC Content |
50.00% |
| Molecular Weight |
23461.3 g/mole |
| nmoles/OD260 |
1.208 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
