Anti-TLR4 Aptamer (CTApt-846)

Specifications

Target Category	Protein
Target	TLR4
Alternative Names	Toll Like Receptor 4; Toll-Like Receptor 4; HToll; ARMD10; CD284; TLR-4; Toll Like Receptor 4 Protein; Homolog Of Drosophila Toll; CD284 Antigen; EC 3.2.2.6; TOLL; TLR4
Gene ID	7099
UniProt ID	O00206
Target Overview	The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene.
Chemical Modification	DNA
Length	60-80 nt
Affinity (Kd)	N/A
Binding Conditions/Buffer	20 mM Tris-HCl, pH 7.4, 150 mM NaCl, 1 mM MgCl₂
GC Content	63
Molecular Weight	24105.6
Extinction Coefficient	737700
nmoles/OD260	1.219

Anti-TLR4 Aptamer(Cat#: CTApt-846)