Anti-IL6R aptamer(Cat#: CTApt-2044)

This product is an aptamer which binds to the IL6R with an affinity of <20 nM.

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5’ Modification
 
3’ Modification
 
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Specifications
Target Category Protein
Target IL6R
Alternative Names Interleukin 6 Receptor; Membrane Glycoprotein 80; Gp80 ; Interleukin-6 Receptor Subunit Alpha; IL-6 Receptor Subunit Alpha; CD126 Antigen; IL-1Ra; IL-6RA; CD126; IL-6R; IL6RA; Interleukin 6 Receptor Subunit Alpha; IL-6R Subunit Alpha; IL-6R-Alpha; IL-6R-1; IL-6R 1; IL6QTL; HIES5; IL6RQ; IL6Q; IL6R
Gene ID 3570
UniProt ID P08887
Target Overview This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been identified in this gene. A pseudogene of this gene is found on chromosome 9.
Chemical Modification RNA
Length 20-40 nt
Affinity (Kd) <20 nM
Binding Conditions/Buffer 137 mM NaCl; 2.7 mM KCl; 6.5 mM Na2HPO4; 1.5 mM KH2PO4 and 3 mM MgCl2 at pH 7.5
GC Content 0.74
Molecular Weight 6003.9
nmoles/OD260 4.485

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For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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