Anti-Influenza virus A HA protein Aptamer(Cat#: CTMM-0124-TT46)

This product is an aptamer which binds to the Influenza virus A HA protein with an affinity of 50-200 nM.

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Specifications
Target Category Protein
Target HA
Alternative Names Hemagglutinin
Gene ID 956529
UniProt ID P03452
Target Overview Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
Type DNA
Species Reactivity Virus
Length 50-100 nt
Affinity (Kd) 50-200 nM
Binding Conditions/Buffer 20 mM HEPES, 120 mM NaCl, 1 mM MgCl₂, 1 mM CaCl₂, 5 mM KCl, pH 7.35
GC Content 56.41%
Molecular Weight 24198.71 g/mole
nmoles/OD260 1.42

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For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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