Anti-Interleukin 6 (IL-6) Aptamer(Cat#: CTApt-217)

Name: Anti-Interleukin 6 (IL-6) Aptamer
SKU: CTApt-217

This product is an aptamer which binds to the Interleukin 6 (IL-6) with an affinity of <20 nM.

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Summary Published Data Customer Reviews Related Products & Services Resources

Specifications

Target Category	Protein
Target	IL6
Alternative Names	B-cell stimulatory factor 2; CTL differentiation factor; Hybridoma growth factor; Interferon beta-2; CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2
Gene ID	3569
UniProt ID	P05231
Target Overview	This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2).
Chemical Modification	Chimeric
Type	DNA
Length	<50 nt
Affinity (Kd)	<20 nM
Binding Conditions/Buffer	20 mM tris-HCl, pH 7.2, 140 mM NaCl, 5 mM KCl
GC Content	42%
Molecular Weight	9578.3 g/mole
Extinction Coefficient	227300 L/(mole·cm)
nmoles/OD260	3.111

Published Data

Fig.1 Assessing the efficacy of IL-6 aptamer-based sensors in complex samples.

To enable early detection of cancer and sepsis, a non-invasive assay for IL-6 is an important clinical breakthrough, aiding in cancer management and sepsis diagnosis. This study introduces a capacitive electrochemical impedance spectroscopy platform for IL-6 detection in human serum, suitable for point-of-care (POC) applications. IL-6 was specifically recognized via two systems: one using anti-IL6 antibody covalently bonded to a gold surface with a binary self-assembled monolayer, and another using an IL-6-specific aptamer chemisorbed onto the surface. Analytical performance was tested in both buffer and 10% serum, employing a cost-effective flexible gold sensor array, informing future POC devices.

Sánchez-Salcedo, Raquel, et al. "Comparing nanobody and aptamer-based capacitive sensing for detection of interleukin-6 (IL-6) at physiologically relevant levels." Analytical and Bioanalytical Chemistry 415.29 (2023): 7035-7045.

Customer Review

Generated high-quality data, leading to meaningful and insightful results

Excellent

The use of this aptamer improved the overall quality and reliability of our research findings.

Convenient storage

Excellent

Aptamer maintained stability over extended periods, providing a longer shelf life. Convenient storage conditions without compromising aptamer performance.

Very good specificity

Excellent

It showed no cross-reactivity with other molecules and is highly selective for IL-6.

If you're in need of a reliable tool, this is definitely worth the investment

Excellent

Excellent prompt service combined with top-notch quality makes the anti-IL-6 aptamer a great purchase. After several weeks of usage, the successful results have clearly justified the expenditure.

Instant, consistent results and easy to use

Excellent

The aptamer worked perfectly in my experimental setup. I appreciate the concise, yet comprehensive, product information that accompanied it too - it made integration into existing processes a breeze.

For Research Use Only. Not for Diagnostic or Therapeutic Applications.

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