Anti-MANF Aptamer SELEX Service(Cat#: CTApt-2341)

This is an aptamer development services to screening aptamers binds to the MANF with an affinity of 1nM~1μM.

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Summary

Specifications
Target Category Protein
Target MANF
Alternative Names Mesencephalic Astrocyte Derived Neurotrophic Factor; Mesencephalic Astrocyte-Derived Neurotrophic Factor; ARP; Arginine-Rich, Mutated In Early Stage Tumors; ARMET; Arginine-Rich Protei; Protein ARMET; MANF
Gene ID 7873
UniProt ID P55145
Target Overview The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.
Chemical Modification N/A
Type DNA
Length 20-80 nt
Affinity (Kd) 1nM~1μM
Binding Conditions/Buffer PBS; buffer system with Serum; other
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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