Anti-MLH1 Aptamer SELEX Service(Cat#: CTApt-771)

Name: Anti-MLH1 Aptamer SELEX Service
SKU: CTApt-771
Rating: 5 (1 reviews)

This is an aptamer development services to screening aptamers binds to the MLH1 with an affinity of 1nM~1μM.

Certificate of Analysis Lookup

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Lot Number

Specifications

Target Category	Protein
Target	MLH1
Alternative Names	FCC2; COCA2; HNPCC; hMLH1; HNPCC2
Gene ID	4292
UniProt ID	P40692
Target Overview	The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).
Chemical Modification	N/A
Type	DNA
Length	20-80 nt
Affinity (Kd)	1nM~1μM
Binding Conditions/Buffer	PBS; buffer system with Serum; other