Anti-OX40 Aptamer(Cat#: CTApt-M-1981)
This product is an aptamer which binds to the Murine OX40 with an affinity of <20 nM.
Specific Inquiry 
Specifications
| Target Category |
Protein |
| Target |
Murine OX40 |
| Alternative Names |
TNF Receptor Superfamily Member 4; TXGP1L; ACT35; CD134; OX40; TAX Transcriptionally-Activated Glycoprotein 1 Receptor; Tumor Necrosis Factor Receptor Superfamily Member 4; OX40L Receptor; ACT35 Antigen; CD134 Antige; Tax-Transcriptionally Activated Glycoprotein 1 Recepto; Tumor Necrosis Factor Receptor Superfamily, Member 4; Lymphoid Activation Antigene ACT35; OX40 Cell Surface Antigen; OX40 Homologue; ATC35 Antigen; OX40 Antigen; IMD16 |
| Gene ID |
7293 |
| UniProt ID |
P43489 |
| Target Overview |
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. |
| Chemical Modification |
2'-F-RNA |
| Length |
80-100 nt |
| Affinity (Kd) |
<20 nM |
| Binding Conditions/Buffer |
Binding Buffer: 150 mM NaCl, 2 mM CaCl2, and 20 mM Hepes (pH 7.4) |
| GC Content |
0.5875 |
| Molecular Weight |
25857.45 g/mole |
| Extinction Coefficient |
783300 L/(mole·cm) |
| nmoles/OD260 |
1.28 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
