Anti-SLC12A1 Aptamer SELEX Service(Cat#: CTApt-804)

This is an aptamer development services to screening aptamers binds to the SLC12A1 with an affinity of 1nM~1μM.

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Summary

Specifications
Target Category Protein
Target SLC12A1
Alternative Names Solute Carrier Family 12 Member; NKCC2; Solute Carrier Family 12 (Sodium/Potassium/Chloride Transporter), Member; Bumetanide-Sensitive Sodium-(Potassium)-Chloride Cotransporter; Kidney-Specific Na-K-Cl Symporter; Solute Carrier Family 12 (Sodium/Potassium/Chloride Transporters), Member; Na-K-2Cl Cotransporter; NKCC2A Variant A; SLC12A1; BSC1
Gene ID 6557
UniProt ID Q13621
Target Overview This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.
Chemical Modification N/A
Type DNA
Length 20-80 nt
Affinity (Kd) 1nM~1μM
Binding Conditions/Buffer PBS; buffer system with Serum; other
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
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