This is an aptamer development services to screening aptamers binds to the SNCA with an affinity of 1nM~1μM.
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| Target Category | Protein |
| Target | SNCA |
| Alternative Names | Synuclein Alpha; Alpha-Synuclein; NACP; Synuclein, Alpha (Non A4 Component Of Amyloid Precursor) ; PARK1; PD1; Parkinson Disease (Autosomal Dominant, Lewy Body) 4; Non A4 Component Of Amyloid Precursor; Non-A4 Component Of Amyloid Precursor; Non A-Beta Component Of AD Amyloid; Non-A Beta Component Of AD Amyloid; Truncated Alpha Synuclein; Synuclein Alpha-140; I+/--Synuclein; Α-Synuclein; PARK4; SNCA |
| Gene ID | 6622 |
| UniProt ID | P37840 |
| Target Overview | Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. |
| Chemical Modification | N/A |
| Type | DNA |
| Length | 20-80 nt |
| Affinity (Kd) | 1nM~1μM |
| Binding Conditions/Buffer | PBS; buffer system with Serum; other |