Name: Anti-von Willebrand Factor Aptamer
SKU: CTApt-M-1317
Rating: 5 (1 reviews)

Specifications

Target Category	Protein
Target	von Willebrand Factor (VWF)
Alternative Names	Von Willebrand Factor; F8VWF; Coagulation Factor VIII VWF; VWD; VWF
Gene ID	7450
UniProt ID	P04275
Target Overview	This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22.
Chemical Modification	2'-F-RNA
Length	80-100 nt
Affinity (Kd)	<20 nM
Binding Conditions/Buffer	For nitrocellulose filter binding assays: Selection Buffer E (20mM HEPES (pH 7.4), 50 mM NaCl, 2 mM CaCl2, and 0.1% BSA) -OR- Selection Buffer F (20mM HEPES (pH 7.4), 150 mM NaCl, 2 mM CaCl2, and 0.1% BSA) For platelet function analysis(performed at RT): Platelet binding buffer: 150 mM NaCl, 20 mM Hepes pH 7.5; 5 mM KCL; 1 mM MgCl2, and 1 M CaCl2.
GC Content	0.5789
Molecular Weight	24492.61 g/mole
Extinction Coefficient	731800 L/(mole·cm)
nmoles/OD260	1.37

Anti-von Willebrand Factor Aptamer(Cat#: CTApt-M-1317)

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