As one of industry leaders in animal models development, Creative Biolabs is professional in tailoring high fat diet-induced obesity model to satisfy our clients' specific research project.

Obesity and Animal Models

Obesity, which has resulted in increasing healthcare burden and decreasing life expectancy, is a key feature of the metabolic syndrome, a set of interrelated risk factors for cardiovascular disease and diabetes, that also includes dysglycemia, raised blood pressure, elevated triglyceride levels, and low high-density lipoprotein cholesterol levels. The incidence of obesity continues to climb worldwide, making it necessary that animal models sharing characteristics of human obesity and its co-morbidities be developed in the quest for novel preventions and/or treatments. Animal models of obesity currently used in research are diverse, including murine genetic loss-of-function mutations, transgenic gain-of-function mutations, polygenic models, and different environmental exposure models. However, the most commonly used animal models of obesity are probably the diet-induced rat or mice obesity (DIO) models because they are believed to mimic better the state of common obesity in humans than most of the genetically modified models for studying polygenic causes of obesity. Also, they may be the best choice for evaluating prospective therapeutics.

High Fat Diet-Induced Obesity Model Fig.1 A summary of how a study on diet induced
obesity in mice was performed.

High Fat Diet-Induced Obesity Models

High fat (HF) diet can lead to increased body weight and diabetes in various strains of mice and rats, while different strains exhibit different responses to a varying degree.

In mice, the B6 mouse is a particularly good model because when fed ad libitum with a high-fat diet, they develop obesity, hyperinsulinemia, hyperglycemia, and hypertension, which, to a very great degree resemble human metabolic derangements. Further, the metabolic abnormalities of B6 mouse closely parallel that of human obesity progression pattern. Besides the C57BL/6J mouse, other stains such as AKR/J and DBA/2J mice are also very responsive to high-fat diet. In brief, lots of factors need to be considered carefully when choosing an experimental model, including diet composition, mouse background, gender, environmental factors and so on.

In rats, Wistar and Sprague-Dawley (SD) Outbred Rat are preferentially used standard models, which are characterized by obesity, hyperglycemia, hypertriglyceridemia, and hyperleptinemia, mimicking the pathophysiology of human obesity and metabolic syndrome. Compared to mice, their larger size benefits the evaluation of some metabolic parameters such as blood pressure.

As the leading services provider for obesity mechanism study and anti-obesity drug development, Creative Biolabs is capable of offering various assessments including:

  • Body Composition Measurement
  • Measurement of Food Intake
  • Blood Pressure
  • Glucose Tolerance Test
  • Insulin Level Measurement
  • Insulin Tolerance Test
  • Histology or Tissue Analysis

Additionally, Creative Biolabs also offers other types of rodent metabolic disease models that you may be interested in:

If you are interested in any of these models, please do not hesitate to contact us or directly send us an inquiry for more detailed information.

For lab research use only.



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