Metabolic diseases, which are orchestrated from multiple factors and involved in multiple organs in the body, refer to any of the disorders that disrupt normal metabolism, animal models, especially rodent models, are widely used to mimic human diseases and thus act as a powerful tool for us to improve understanding of the causes and progression of disease symptoms and to test potential therapeutic interventions.

Advantages

Creative Biolabs offers a variety of rodent metabolic disease models including diabetes, obesity, liver dysfunction and so on. Available models cover the range of diet-induced, chemical-induced, surgically-induced as well as genetically engineered models. At Creative Biolabs, we fully understand the importance of choosing appropriate disease models based on the mechanism of action of the tested agent to ensure the success of in vivo pharmacology studies as well as secure the investment of finance and time. Therefore, a well-trained group of scientists will be assigned to your project, working closely with you from the initial experimental design to final data analysis, to ensure the most relevant and reliable results can be achieved.

Measurements

Various parameters or endpoints can be measured and analyzed by Creative Biolabs. Individualized sample collection of blood, adipose tissue and organs are obtained and processed for subsequent analysis. Clinical observations are conducted and biomarkers such as cytokines, blood glucose, and serum insulin levels are measured. Glucose tolerance test (GTT) and insulin tolerance test, as well as histological and immunohistochemical examination, are also included.

Models of Type 1 and Type 2 Diabetes

Diabetes models are typically divided into two groups: type 1 diabetes and type 2 diabetes. Distinct models are utilized to provide essential information about novel drugs to treat and manage these diseases. Diet-induced models are thought to be more reflective of the state of human counterparts, making them better choices for testing prospective treatments. Besides, chemical experimental models have been used for a long time with the advantage of ease of induction and reproductivity. Further, these methods can be incorporated to create new and better models. Apart from these, genetically modified mice and rats are employed as well and because of gene manipuility, they are frequently used.

Schematic representation of the metabolic syndrome Fig.1 Schematic representation of the metabolic syndrome. (Greevenbroek, et al. 2016)

Specific diabetic model available at Creative Biolabs including but not limited to:

Models of Obesity and Liver Diseases

In the meanwhile, Creative Biolabs offers models of obesity and liver diseases such as nonalcoholic fatty liver disease (NAFLD/NASH). Models induced by different diets, chemicals as well as inherent models.

It's worth knowing that Creative Biolabs offers more than well-characterized models, we can provide tailor-made models to a specific project, plus model validation from the literature as well as the development of new models. Customers will receive personalized support from before the project initiates to after the model is successfully delivered. A well-trained group of scientists will be assigned to your project, working closely with you from the initial experimental design to final data analysis, to ensure the most relevant and reliable results can be achieved.

Creative Biolabs is happy to share our cutting-edge technology and extensive expertise in rodent disease models to facilitate our clients' research and project development. Please feel free to inquire us for more detailed information if you are interested in any of these services. In case you do not see the model you are interested in, please contact us and we'll be in touch within 24 hours to let you know if it is feasible.

Reference

  1. Greevenbroek, M. M. J. V.; et al. Dysfunctional adipose tissue and low-grade inflammation in the management of the metabolic syndrome: current practices and future advances. F1000research. 2016, 5:2515.

For lab research use only.



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