LPS-induced Uveitis Model

With experienced scientists specialized in the field of ophthalmology, Creative Biolabs can provide a simple and reproducible LPS-induced uveitis model for our worldwide customer's vision-related drug development. We are committed to being your trusted partner to help you promote your research development with our professional techniques.

What Is Anterior Uveitis?

Consisted of iridocyclitis and iritis, anterior uveitis is a relatively common disease of uncertain etiology that usually appeared in the middle layer of the eye. It is mainly caused by inflammatory responses inside the eye. The symptoms of anterior uveitis include light sensitivity, throbbing eye pain, and blurred vision. The treatments of Uveitis primarily try to eliminate inflammation, alleviate pain, prevent further tissue damage, and restore any loss of vision. Also, it is mainly depended on the type of uveitis a patient displays. This condition can occur as a single episode and subside with proper treatment or may take on a recurrent or chronic nature.

LPS-induced Uveitis Model

The uveitis model is induced by lipopolysaccharide (LPS) which are found in the bacterial cell outer wall. It has been widely used in the evaluation of pharmaceutical products efficacy for the treatment of anterior uveitis and other inflammatory diseases in the eye. There have been reports suggesting that the cell number and protein concentration in the aqueous humor begin to increase 6 hours after the endotoxin injection and reach a peak at 24 hours before gradually decreasing. At Creative Biolabs, product efficacy is evaluated clinically with a slit lamp and by measuring cellular infiltration and protein concentration in the aqueous humor by our experienced scientists.

Fig.1 Clinical and histologic pictures of rat eye during different stages of experimental autoimmune anterior uveitis. (Bora et al, 2008)

Our Capabilities

Creative Biolabs has a comprehensive understanding of ocular diseases along with technical ability to promote our clients' new drugs and treatment development in a cost-effective and timely manner. With an integrated approach to ophthalmology research, we can provide a series of preclinical services for the development of ophthalmic drugs and ocular medical devices. If you are interested in the service we can provide, please click the links below.

• Corneal Neovascularization Model
• Choroidal Neovascularization Model
• Model of Retinal Degeneration & Neuroprotection
• Normotensive & Hypertensive Intraocular Pressure Model
• Allergic Conjunctivitis Model
• Dry Eye Model
• Corneal Wound Healing Model
• Diabetic Macular Edema Model
• Infectious Keratitis Model

We are committed to being your trusted partner to help you promote your research development with our professional techniques. Please feel free to inquire us about the services we can provide. Furthermore, in order to meet specific requirements and various objectives of our clients, Creative Biolabs is proud to provide customized service for you. If you are interested in getting more information about our animal model or drug discovery service, just contact us for more details.

Reference

1. Bora N S, et al. The role of complement in ocular pathology [C] Seminars in immunopathology. Springer-Verlag, 2008, 30(2): 85-95.

For Research Use Only.